Imaging is an essential tool for medical diagnosis. Various technologies have evolved over time, each one providing specific benefits – but also limitations. MSOT is a novel imaging technology. Besides its high spatiotemporal resolution and sensitivity for optical contrast, MSOT imaging comes at relatively low cost and does not expose the patient to health risks associated with radiation or contrast agents. The MSOT Acuity has shown promise in initial clinical trials involving Crohn’s disease, breast cancer, melanoma, scleroderma and vascular disease.
Equipped with a fast-tunable laser and 2D or 3D detectors, the MSOT Acuity / Acuity Echo can be used for real-time visualization of disease-related changes in optical contrast in soft tissue. The MSOT Acuity has a small footprint and is mobile, allowing bedside measurements in clinical research studies.
Most clinical studies with the MSOT Acuity to date have used an arc-shaped 2D detector with 4 MHz center frequency. This detector can visualize optical contrast in a cross-sectional view, at up to 4 cm depth, with an in-plane resolution of approx. 200 µm.
Some clinical studies with the MSOT Acuity have used the 3D detector to leverage its unique capability of acquiring volumetric images with a single laser pulse and displaying volumetric images in real time. Key applications to date using this detector haven been in the areas of skin and breast cancer.
|Technical parameter||MSOT Acuity*||MSOT Acuity Echo**|
|Imaging modes||Optoacoustic||Optoacoustic + Ultrasound (OPUS)|
|Frame rate – optoacoustic||25 Hz||up to 50 Hz|
|Frame rate – ultrasound||n/a||up to 20 Hz|
|Laser wavelength range||660-1300 nm||680-980 nm / 660-1300 nm|
|Peak pulse energy||30 mJ||30 mJ|
|Detector||2D, 4 MHz, 256 elements||Various 2D & 3D detectors|
|Spatial resolution||< 400 µm||80-400 µm (detector-dependent)|
|Data acquisition & processing||viewMSOTc||viewMSOTc, viewMSOTp, iLabs|
|* CE-certification for clinical use pending
** prototype system for clinical research
Two systems to cover a wide scope of clinical research applications