A whole range of applications beyond
tumor, brain and PK imaging

Optoacoustic imaging: extending the imaging toolbox for biomedical scientists

Biomedical research pushes the boundaries to create new therapies or diagnostics. Imaging is an essential tool to discover disease mechanisms and characterize novel materials. iThera Medical’s optoacoustic imaging (OAI) systems extend the imaging toolbox of biomedical scientists.

Localizing inflammation in arthritis

A macrophage-targeting polymer-based probe was used to detect inflammation in the foot of a mouse with LPS-induced inflammation. Similar approaches have been used in other mouse models of arthritis.

MSOT can visualize the distribution of the probe with high sensitivity and specificity in 3D, while providing an anatomical background image based on endogenous tissue contrast from hemoglobin.

A macrophage-specific contrast agent is shown taken up in the mouse paw following LPS-induced inflammation.

Coronal maximum intensity projections of the mouse whole body showing the distribution of a contrast agent specific for brown adipose tissue

Analyzing whole-body probe biodistribution

Repeatable positioning in the MSOT animal holder and fully automated data acquisition enable 3D rendering of cross-sectional images. Whole-body biodistribution of injected contrast agents can be visualized and quantified.

Cell tracking with MSOT

The ability to visualize cells in vivo with MSOT enables investigators to track stem cells, macrophages, or other cells of interest over extended periods of time throughout the whole body.

Dyes and genetic reporters can be used to label cells, producing contrast that can be followed over time in 3D with MSOT.

Implanted cell labeled with gold nanorods were imaged in vivo for up to 40 days.
Brown adipose tissue (BAT) imaged before and after activation with norepinephrine

Functional imaging of fat metabolism

Brown adipose tissue and the Sulzer vein (SV) can be localized with MSOT based on endogenous contrast. MSOT can quantify brown fat metabolism through enhanced hemoglobin levels, as shown in studies with norepinephrine activation of this tissue.

Assessing tumor angiogenesis in high resolution via RSOM

High resolution raster-scanning optoacoustic mesoscopy (RSOM) can non-invasively visualize blood vessel formation during tumor growth based on the endogenous contrast of hemoglobin.

Besides the study of vascular network formation of different tumor types, this also allows to monitor treatment, e.g. for vascular-disrupting agents (VDA).

The same field of view measured 2 and 7 days post implantation of melanoma cells
Cross-sectional MSOT and R-UCT image of a tumor-bearing mouse

Maximizing tissue contrast with tomographic ultrasound

Conventional ultrasound uses handheld linear arrays, enabling flexibility of use, but at the cost of user dependence. The MSOT inVision enables reflection-mode ultrasound computer tomography (R-UCT), allowing the user to achieve repeatable positioning and cross-sectional, whole-body ultrasound imaging of the mouse.

R-UCT offers complementary contrast in MSOT experiments, providing a second source of soft tissue contrast that permits the visualization of structures that would otherwise not be well distinguished by MSOT.

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Applications for Preclinical Research

Find out more about the use of our Technology for Preclinical Research

Tumor
characterization

Organ function
assessment

Brain imaging

Nanoparticle
tracking

Other preclinical
applications

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