PRECLINICAL FIBROSIS OF THE
Lethal muscular diseases like Duchenne Muscular Dystrophy (DMD) pose significant burden not only on patients, but also their families and the healthcare system. The current status of severity and therapy assessment relies on functional tests involving physical challenges, which are highly variable and unsuitable for young infants and other non-ambulant patients. Optoacoustic imaging could offer an objective and quantitative tool to monitor the status of such patients. A translational study in piglets could show increased collagen content in the distal extremities of the DMD group, allowing for an easy and objective longitudinal assessment of disease progression and treatment outcome.