CLINICAL FIBROSIS OF THE

INTEGUMENTARY SYSTEM

Systemic sclerosis (SSc) manifests as fibrosis of the skin and internal organs and is associated with progressive microvascular dysfunction. Optoacoustic imaging (OAI) provides the opportunity to assess such dysfunction directly and non-invasively by visualizing changes in vascular morphology as well as by quantifying the hemoglobin concentration in affected tissues. Recent clinical trials using both MSOT and RSOM have demonstrated the potential of OAI for the diagnostic work-up of SSc. 

Reduction of perfusion in superficial tissue layers of a finger of a scleroderma patient, with total hemoglobin (HbT) shown as a pseudocolor overlay on a grayscale ultrasound image. Scales indicates position in millimeters.

Detection of microvascular dysfunction in systemic sclerosis

Systemic sclerosis manifests as fibrosis of the skin and internal organs and is associated with progressive microvascular dysfunction. 

Optoacoustic imaging with MSOT provides the opportunity to study and quantify such dysfunction directly and non-invasively, as was done in a recent clinical trial. 

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