Biomedical research pushes the boundaries to create new therapies or diagnostics. Imaging is an essential tool to discover disease mechanisms and characterize novel materials. iThera Medical’s optoacoustic imaging (OAI) systems extend the imaging toolbox of biomedical scientists.
A macrophage-targeting polymer-based probe was used to detect inflammation in the foot of a mouse with LPS-induced inflammation. Similar approaches have been used in other mouse models of arthritis.
MSOT can visualize the distribution of the probe with high sensitivity and specificity in 3D, while providing an anatomical background image based on endogenous tissue contrast from hemoglobin.
MSOT can visualize the distribution of the probe with high sensitivity and specificity in 3D, while providing an anatomical background image based on endogenous tissue contrast from hemoglobin.
Repeatable positioning in the MSOT animal holder and fully automated data acquisition enable 3D rendering of cross-sectional images. Whole-body biodistribution of injected contrast agents can be visualized and quantified.
The ability to visualize cells in vivo with MSOT enables investigators to track stem cells, macrophages, or other cells of interest over extended periods of time throughout the whole body.
Dyes and genetic reporters can be used to label cells, producing contrast that can be followed over time in 3D with MSOT.
Brown adipose tissue and the Sulzer vein (SV) can be localized with MSOT based on endogenous contrast. MSOT can quantify brown fat metabolism through enhanced hemoglobin levels, as shown in studies with norepinephrine activation of this tissue.
High resolution raster-scanning optoacoustic mesoscopy (RSOM) can non-invasively visualize blood vessel formation during tumor growth based on the endogenous contrast of hemoglobin.
Besides the study of vascular network formation of different tumor types, this also allows to monitor treatment, e.g. for vascular-disrupting agents (VDA).
Conventional ultrasound uses handheld linear arrays, enabling flexibility of use, but at the cost of user dependence. The MSOT inVision enables reflection-mode ultrasound computer tomography (R-UCT), allowing the user to achieve repeatable positioning and cross-sectional, whole-body ultrasound imaging of the mouse.
R-UCT offers complementary contrast in MSOT experiments, providing a second source of soft tissue contrast that permits the visualization of structures that would otherwise not be well distinguished by MSOT.
Applications for Preclinical Research
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