With high spatial resolution and real-time imaging, multispectral optoacoustic tomography (MSOT) has the potential to offer performance not possible with traditional optical imaging modalities. Hemodynamics, genetic reporters and probe accumulation can be monitored over time through intact skin and skull, allowing for anatomical, functional and molecular imaging of the brain in small animals.
Vascular structures can be seen in the rodent brain through intact skin and skull. These landmarks correlate with structures such as the cortex, superior sagittal sinus, and inferior cerebral vessel.
Genetic reporters can be used to label glioblastoma cells, enabling three-dimensional visualization of tumor growth in the brain over time.
Functional MSOT measurements quantifying oxygenation in the brain can be used in combination with MRI measurements in Alzheimer’s disease mouse models to determine the cerebral metabolic rate of oxygen.
Similar to BOLD-MRI, functional MSOT imaging shows short term deficits of oxygenation following stroke that return to normal after reperfusion.
Applications for Preclinical Research