The assessment of microvasculature, tissue perfusion and oxygenation is critical for the diagnosis and treatment monitoring of skin diseases. Conventional techniques like optical microscopy can only visualize superficial skin features due to strong photon scattering in tissue while ultrasound lacks contrast for visualizing small vascular structures.

While raster-scanning optoacoustic mesoscopy (RSOM) combines the best of optical and ultrasound technology, providing intrinsic optical tissue contrast down to 10-20 µm resolution at a depth penetration of several millimeters, multispectral optoacoustic tomography (MSOT) enables applications that require bulk tissue measurements of hemoglobin concentration and tissue oxygenation.

Image gallery

RSOM imaging of psoriatic and adjacent healthy skin
 
RSOM imaging of psoriatic and adjacent healthy skin
RSOM imaging of psoriatic and adjacent healthy skin
Quantification of skin parameters associated with psoriasis
  • Aguirre J et al.,
    Precision assessment of label-free psoriasis biomarkers with ultra-broadband optoacoustic mesoscopy,
    Nat. Biomed. Eng. 1, 0068 (2017). DOI:10.1038/s41551-017-0068.
    Link
  • Application Note: Psoriasis RSOM
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