Beating heart.

Cardiac dysrhythmia is characterized by regular and irregular changes in the heart beats. This condition can predispose an individual to a life-threatening stroke and/or emphysema, and, in some cases, can be a side effect of drug treatment. Evaluating potential cardiac toxicities is a critical step in the drug discovery process. 

Being able to acquire data at a rate of up to 100 frames per second, MSOT imaging can be used to observe both ventricles as the heart beats, allowing the visualization of normal and arrhythmic cardiac function in vivo. In addition, cardiac hypertrophy can also be visualized.

MSOT can thus be used for general assessment of heart function, and also to demonstrate pathological changes associated with cardiac disease or drug treatment.

  • Hasiao-Chun AL et al.,
    Non-invasive volumetric optoacoustic imaging of cardiac cycles in acute myocardial infarction model in real-time,
    Proc. SPIE 10064, Photons Plus Ultrasound: Imaging and Sensing 2017, 100641D (March 3, 2017). DOI:10.1117/12.2254818.
  • Taruttis A et al.,
    Multispectral Optoacoustic Tomography of Myocardial Infarction,
    Photoacoustics (Vol. 1, Issue 1, March 2013). DOI: 10.1016/j.pacs.2012.11.001.
  • Taruttis A et al.,

    Motion Clustering for Deblurring MSOT Images of the Mouse Heart,
J. Biomed Opt. 17, 016009 (Feb 06, 2012). DOI: 10.1117/1.JBO.17.1.016009.
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