Multimodal cell tracking by combining gold nanorods and reporter genes
Dr Raphael Levy and Dr Antonius Plagge, University of Liverpool, UK
Understanding the fate of exogenous cells after implantation is important for clinical applications. Preclinical studies allow imaging of cell location and survival. Labelling with nanoparticles enables high sensitivity detection, but cell division and cell death cause signal dilution and false positives. By contrast, genetic reporter signals are amplified by cell division.This multimodal cell tracking approach could be applied widely for cancer and regenerative medicine research to monitor short- and long-term biodistribution, tumor formation and metastasis.
This webinar will focus on the use of MSOT to address the following topics:
- advantages and limitations of multimodal cell tracking approaches
- tracking cells immediately after injection into the blood stream of a mouse
- monitoring tumor growth over time using genetic reporters