iThera Webinars

Experience scientists describe how they use iThera’s technologies

Preclinical research webinars

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March 2019
Liver Injury and Tumor Metastasis Imaging with MSOT
Prof Dr Shuizhu Wu, State Key Laboratory of Luminescent Materials & Devices, College of Materials Science & Engineering, South China University of Technology
The development of accurate, non-invasive, fast-binding imaging contrast agents tailored to a specific pathological biomarker will deliver to the researcher & clinician tools to gauge the severity and progression of disease. By targeting specific enzymatic pathways through the use of activatable probes, it is possible to increase sensitivity and specificity of detection which, when combined with an imaging technology such as Multispectral Optoacoustic Tomography (MSOT), can give great insights into areas such as organ toxicity and cancer. This webinar demonstrates how the optoacoustic effect can be used for imaging orthotopic tumors and for tumor biology investigation using activatable probes in combination with MSOT.
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August 2018
Multimodal cell tracking by combining gold nanorods and reporter genes
Dr Raphael Levy and
Dr Antonius Plagge, University of Liverpool, UK
Understanding the fate of exogenous cells after implantation is important for clinical applications. Preclinical studies allow imaging of cell location and survival. Labelling with nanoparticles enables high sensitivity detection, but cell division and cell death cause signal dilution and false positives. By contrast, genetic reporter signals are amplified by cell division.This multimodal cell tracking approach could be applied widely for cancer and regenerative medicine research to monitor short- and long-term biodistribution, tumor formation and metastasis. This webinar focusses on the use of MSOT to address the following topics: - advantages and limitations of multimodal cell tracking approaches - tracking cells immediately after injection into the blood stream of a mouse - monitoring tumor growth over time using genetic reporters
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February 2018
Imaging tumor vascularization in high resolution with raster-scanning optoacoustic mesoscopy (RSOM)
Dr Katja Haedicke, Memorial Sloan Kettering Cancer Center, New York
Tumor vasculature is the main source for oxygen and nutrient supply into the tumor tissue as well as the first route for tumor proliferation and metastasis formation. Therefore, it is of great interest to obtain non-invasive and high-resolution images of the entire tumor vascular network, not only to diagnose and characterize tumors but also to monitor treatment outcomes. In this context, the new imaging modality RSOM (raster-scanning optoacoustic mesoscopy) can highly improve the way we monitor and evaluate tumor vascularization by using the endogenous contrast of hemoglobin.
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November 2017
Assessing tissue oxygenation in small animal tumor models using MSOT
Dr Sarah Bohndiek, University of Cambridge
Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar provides insights into how oxygen enhanced optoacoustic tomography (OE-OT), exploiting an oxygen gas challenge, visualizes the spatiotemporal heterogeneity of tumor vascular function.
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June 2017
Molecular imaging of cancer biomarkers using multispectral optoacoustic tomography (MSOT)
Lacey McNally, PhD, Associate Professor, University of Louisville School of Medicine;
Clinton Hupple, MSc, Application Specialist, iThera Medical
Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar provides insights into how MSOT can be used for molecular imaging and specifically on recent findings from preclinical studies in orthotopic pancreatic tumor models.
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July 2014
MSOT for Imaging Biodistribution and Pharmacokinetics
Wouter Driessen, PhD, Probe Development Scientist, iThera Medical
Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar provides insights into how MSOT can be used to visualize and quantify probe biodistribution as well as clearance and related pharmacokinetic (PK) parameters.
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January 2014
MSOT - A Versatile New Imaging Modality for Cancer Research
Neal Burton, PhD, Application Specialist, iThera Medical
Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar provides insights into how MSOT can be used to visualize and quantify processes related to cancer progression, both with intrinsic contrast and exogenous probes.
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December 2012
MSOT for Biomedical Research
Neal Burton, PhD, Application Specialist, iThera Medical
Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. Today, MSOT allows the study of disease processes on a molecular level as well as the analysis of pharmacokinetic and biodistribution properties for new substances in small animals. For the future, MSOT also promises to become a valuable tool for clinical diagnostics. This webinar provides an overview on MSOT technology as well as applications in preclinical research and an outlook towards clinical translation.

Clinical research webinars

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February 2016
Multispectral Optoacoustic Tomography (MSOT) enters the clinic
Joachim Klode MD, Associate Professor, Dermatologist, University Hospital Essen;
Neal C. Burton PhD, Senior Application Specialist, iThera Medical
Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar focusses on the use of MSOT in the clinic and addresses the following topics: - introduction to the new “MSOT Acuity" clinical scanner and overview on the range of potential clinical MSOT applications - data of the first clinical trial using MSOT, as published in 12/2015 in Science Translational Medicine. This clinical trial demonstrates the feasibility of using MSOT to detect sentinel lymph nodes (SLNs) and assess SLN status in malignant melanoma patients.
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