Experience scientists describe how they use iThera’s technologies

The development of accurate, non-invasive, fast-binding imaging contrast agents tailored to a specific pathological biomarker will deliver to the researcher & clinician tools to gauge the severity and progression of disease. By targeting specific enzymatic pathways through the use of activatable probes, it is possible to increase sensitivity and specificity of detection which, when combined with an imaging technology such as Multispectral Optoacoustic Tomography (MSOT), can give great insights into areas such as organ toxicity and cancer. This webinar demonstrates how the optoacoustic effect can be used for imaging orthotopic tumors and for tumor biology investigation using activatable probes in combination with MSOT.

Understanding the fate of exogenous cells after implantation is important for clinical applications. Preclinical studies allow imaging of cell location and survival. Labelling with nanoparticles enables high sensitivity detection, but cell division and cell death cause signal dilution and false positives. By contrast, genetic reporter signals are amplified by cell division.This multimodal cell tracking approach could be applied widely for cancer and regenerative medicine research to monitor short- and long-term biodistribution, tumor formation and metastasis. This webinar focusses on the use of MSOT to address the following topics: - advantages and limitations of multimodal cell tracking approaches - tracking cells immediately after injection into the blood stream of a mouse - monitoring tumor growth over time using genetic reporters

Tumor vasculature is the main source for oxygen and nutrient supply into the tumor tissue as well as the first route for tumor proliferation and metastasis formation. Therefore, it is of great interest to obtain non-invasive and high-resolution images of the entire tumor vascular network, not only to diagnose and characterize tumors but also to monitor treatment outcomes. In this context, the new imaging modality RSOM (raster-scanning optoacoustic mesoscopy) can highly improve the way we monitor and evaluate tumor vascularization by using the endogenous contrast of hemoglobin.

Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar provides insights into how oxygen enhanced optoacoustic tomography (OE-OT), exploiting an oxygen gas challenge, visualizes the spatiotemporal heterogeneity of tumor vascular function.

Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar provides insights into how MSOT can be used for molecular imaging and specifically on recent findings from preclinical studies in orthotopic pancreatic tumor models.

Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar provides insights into how MSOT can be used to visualize and quantify probe biodistribution as well as clearance and related pharmacokinetic (PK) parameters.

Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar provides insights into how MSOT can be used to visualize and quantify processes related to cancer progression, both with intrinsic contrast and exogenous probes.

Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. Today, MSOT allows the study of disease processes on a molecular level as well as the analysis of pharmacokinetic and biodistribution properties for new substances in small animals. For the future, MSOT also promises to become a valuable tool for clinical diagnostics. This webinar provides an overview on MSOT technology as well as applications in preclinical research and an outlook towards clinical translation.

Multispectral Optoacoustic Tomography (MSOT) utilizes the photoacoustic effect to visualize and quantify anatomical, functional and molecular information, in vivo, in deep tissue and in real time. This webinar focusses on the use of MSOT in the clinic and addresses the following topics: - introduction to the new “MSOT Acuity" clinical scanner and overview on the range of potential clinical MSOT applications - data of the first clinical trial using MSOT, as published in 12/2015 in Science Translational Medicine. This clinical trial demonstrates the feasibility of using MSOT to detect sentinel lymph nodes (SLNs) and assess SLN status in malignant melanoma patients.