MSOT NOW AVAILABLE FOR CLINICAL RESEARCH.

While the routine clinical deployment of MSOT is still uncharted territory, the technology has already proven that it can make an impact in various point-of-care diagnostic applications in humans. A variety of clinical studies have been conducted or are currently ongoing, including such in the fields of melanoma, inflammatory bowel disease (Crohn's disease), breast cancer, thyroid cancer, and peripheral vascular disease.

The unique MSOT ability to visualize intrinsic tissue contrast, blood oxygenation, melanin, lipids and chromophores that are already FDA-approved for clinical use (i.e. ICG, methylene blue), circumvents the major bottleneck of new imaging technologies with the potential to accelerate clinical propagation.

Based on the real-time multispectral imaging technology proven in iThera Medical’s MSOT inSight / inVision small animal imaging systems, an MSOT imaging system for exploratory clinical research, the MSOT Acuity, is now available.

Equipped with a fast-tunable 50 Hz laser and custom-made 2D or 3D detectors the MSOT Acuity can be used for real-time visualization and quantification of disease-related changes in tissue chromophore distribution and concentration.

For more information: play video

The MSOT Acuity has already been used in several investigator initiated trials.

Technical information

  • Single-wavelength imaging at up to 50 Hz frame rate
  • Real-time spectral component visualization at up to 25 Hz frame rate
  • Penetration depth of 1-3 cm
  • Cross-sectional spatial in-plane resolution of 80-250 μm
  • High-energy / fast-tunable laser system (50 Hz / 30 mJ)
  • Custom-made 2D or 3D tomographic ultrasound detectors (128-512 elements, 2.5-10 MHz)
  • Image acquisition fully automated
  • Data post-processing suite for spectral and temporal analysis
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    Multi-Spectral Optoacoustic Tomography (MSOT) of human breast cancer,
    Clin Cancer Res. 2017 Sep 12. DOI: 10.1158/1078-0432.CCR-16-3200.
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    Multispectral optoacoustic tomography of the human breast: characterisation of healthy tissue and malignant lesions using a hybrid ultrasound-optoacoustic approach,
    Eur Radiol. 2017 Aug 7. DOI: 10.1007/s00330-017-5002-x.
    Link
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    Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept,
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    Noninvasive real-time characterization of non-melanoma skin cancers with handheld optoacoustic probes,
    Photoacoustics. 2017 Jun 4;7:20-26. DOI: 10.1016/j.pacs.2017.05.003.
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    Multispectral Optoacoustic Tomography for Assessment of Crohn’s Disease Activity,
    N Engl J Med. 2017 Mar 30;376(13):1294-6. DOI: 10.1056/NEJMc1612455.
    Link
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    Structural and functional 3D mapping of skin tumours with non-invasive multispectral optoacoustic tomography,
    Skin Res Technol. 2016 Nov 2. DOI: 10.1111/srt.12326.
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    Radiology. 2016 Jul 4:152160. DOI: 10.1148/radiol.2016152160.
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    Multispectral optoacoustic tomography in Crohn's disease: Non-invasive imaging of disease activity,
    Gastroenterology. 2016 Jun 3. DOI: 10.1053/j.gastro.2016.05.047.
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    Current and Emerging Clinical Applications of Multispectral Optoacoustic Tomography (MSOT) in Oncology,
    Clin Cancer Res. 2016 May 20. PII: clincanres.0573.2016.
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    Performance of a Multispectral Optoacoustic Tomography (MSOT) System equipped with 2D vs. 3D Handheld Probes for Potential Clinical Translation,
    PACS, Volume 4, Issue 1, March 2016. DOI:10.1016/j.pacs.2015.12.001.
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    Structural and Functional Analysis of Intact Hair Follicles and Pilosebaceous Units by Volumetric Multispectral Optoacoustic Tomography,
    J Invest Dermatol. 2015 Dec 30. DOI: 10.1016/j.jid.2015.09.001.
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    Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,
    Sci. Transl. Med. 09 Dec 2015. DOI: 10.1126/scitranslmed.aad1278.
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    Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature,
    Optics Letters, Vol. 39, Issue 14, pp. 4061-4064 (2014). DOI: 10.1364/OL.39.004061.
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  • X. Luís Deán-Ben and Daniel Razansky,
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    Light: Science & Applications (2014) 3, e137; DOI:10.1038/lsa.2014.18.
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  • X. Luís Deán-Ben and Daniel Razansky,
    Functional optoacoustic human angiography with handheld video rate three dimensional scanner,
    Photoacoustics (Vol 1, Issue 3-4, Dec 2013). DOI: 10.1016/j.bbr.2011.03.031.
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  • X. Luís Deán-Ben and Daniel Razansky,
    Portable spherical array probe for volumetric real-time optoacoustic imaging at centimeter-scale depths,
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  • Garcia-Allende PB et al.,
    Enriching the interventional vision of cancer with fluorescence and optoacoustic imaging,

    J Nucl Med. 2013 May;54(5):664-7. DOI: 10.2967/jnumed.111.099796. Epub 2013 Apr 4. Review.
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  • Deán-Ben et al.,
    Volumetric real-time tracking of peripheral human vasculature with GPU-accelerated three-dimensional optoacoustic tomography,

    IEEE transactions on medical imaging 07/2013; DOI:10.1109/TMI.2013.2272079.
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  • Buehler A et al.,
    Real-time handheld multispectral optoacoustic imaging,

    Optics Letters, Vol. 38, Issue 9, pp. 1404-1406 (2013). DOI: 10.1364/OL.38.001404.
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