Participate in an imaging revolution.

iThera Medical offers the next generation in molecular imaging. 
Introducing MSOT - Multispectral Optoacoustic Tomography.

With its unique ability to accurately visualize and quantify tissue molecules, nanoparticles, biomarkers and optical agents, in vivo and in real time, through several centimeters of tissue, MSOT stands at the forefront of the next era in biomedical imaging.

MSOT Clinical Translation

Based on the real-time multispectral imaging technology proven in iThera Medical’s MSOT inSight / inVision small animal imaging systems, a handheld MSOT imaging system for translational and clinical research use, the MSOT Acuity, is now available (not yet approved as a medical device by FDA or CE).

For more information: click here or play video.

MSOT Small Animal Imaging

iThera Medical offers a range of small animal scanners with varying hardware and software configurations. All systems enable whole-body deep-tissue imaging in real time.

For more information: click here.

Hybrid OA / US Technology

iThera Medical recently launched an integrated OPtoacoustic / UltraSound (OPUS) imaging technology. The MSOT inVision 512-echo is the world's first hybrid tomographic OPUS imaging system, providing unparalelled and user-independent image quality, in real time, throughout the entire animal cross-section.

For more information: click here.

Application Highlight: DCE-MSOT

MSOT has the capability to capture fast processes in vivo with high spatiotemporal resolution. Per-pixel analysis allows fitting of a pharmacokinetic model and calculation of parametric maps. Related applications include perfusion and probe targeting / clearance studies: see poster

xPLORE Probes

iThera Medical markets a proprietary line of probes optimized for the use with MSOT. The initial portfolio of three xPLORE© probes consists of two targeted reagents for the use in disease models related to cancer and inflammation as well as one blood pool agent with long circulation time.

For more information: click here.

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    Multispectral optoacoustic tomography of the human breast: characterisation of healthy tissue and malignant lesions using a hybrid ultrasound-optoacoustic approach,
    Eur Radiol. 2017 Aug 7. DOI: 10.1007/s00330-017-5002-x.
    Link
  • Deng X et al.,
    A Hollow-Structured CuS@Cu2S@Au Nanohybrid: Synergistically Enhanced Photothermal Efficiency and Photoswitchable Targeting Effect for Cancer Theranostics,
    Adv. Mater. 2017, 1701266. DOI: 10.1002/adma.201701266.
    Link
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    Dynamic and accurate assessment of acetaminophen-induced hepatotoxicity by integrated photoacoustic imaging and mechanistic biomarkers in vivo,
    TAAP. 332 (2017) 64-74. DOI: 10.1016/j.taap.2017.07.019.
    Link
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    Monodisperse Dual Plasmonic Au@Cu2-xE (E= S, Se) Core@Shell Supraparticles: Aqueous Fabrication, Multimodal Imaging, and Tumor Therapy at in Vivo Level,
    ACS Nano. 2017 Aug 1. DOI: 10.1021/acsnano.7b03369.
    Link
  • Tomaszewski MR et al.,
    Oxygen Enhanced Optoacoustic Tomography (OE-OT) Reveals Vascular Dynamics in Murine Models of Prostate Cancer,
    Theranostics 2017; 7(11):2900-2913. DOI:10.7150/thno.19841.
    Link
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    Flow-mediated dilatation test using optoacoustic imaging: a proof-of-concept,
    Biomed Opt Express. 2017 Jul 1; 8(7): 3395–3403. DOI: 10.1364/BOE.8.003395.
    Link
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    "In vivo self-assembled" nanoprobes for optimizing autophagy-mediated chemotherapy,
    Biomaterials. 2017 Oct;141:199-209. DOI: 10.1016/j.biomaterials.2017.06.042. Epub 2017 Jun 30.
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    Dual-mode Imaging-Guided Synergistic Chemo- and Magnetohyperthermia Therapy in a Versatile Nanoplatform to Eliminate Cancer Stem Cells,
    ACS Appl Mater Interfaces. 2017 Jul 19;9(28):23497-23507. DOI: 10.1021/acsami.7b06393.
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    Design of TPGS-functionalized Cu3BiS3 nanocrystals with strong absorption in the second near-infrared window for radiation therapy enhancement,
    Nanoscale. 2017 Jun 22;9(24):8229-8239. DOI: 10.1039/c7nr02213a.
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    Biocompatible PEGylated bismuth nanocrystals: “All-in-one” theranostic agent with triple-modal imaging and efficient in vivo photothermal ablation of tumors,
    Biomaterials. 2017 Oct;141:284-295. DOI: 10.1016/j.biomaterials.2017.06.033.
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