Measurement of kidney function.

The kidneys are an important target in the study of pharmacokinetics. Water soluble drugs or metabolites are filtered by the glomeruli and excreted into the urine.

MSOT technology can be used in vivo to visualize localization of drugs in the kidney and to assess kidney function in real time. Non-targeted probes that are filtered by the kidneys can also be used to establish basic healthy kidney function, which can then be compared to diseased animals in order to characterize the extent of kidney disease.

Probe accumulation in kidney region

Images: IRDye800CW (LI-COR Biosciences) was injected in vivo and its spectral signature was unmixed at multiple time points following injection, allowing the visualization and quantification of probe uptake and excretion in the kidneys.

Image left: Regions of interest in the left renal cortex (orange) and pelvis (black)
Image right: Contrast evolution over time in both regions of interest

Taruttis A, Morscher S, Burton NC, Razansky D, Ntziachristos V, Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple Organs, PLoS ONE 2012, 7(1):e30491.

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    Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy,
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