Measurement of blood oxygenation.

The oxygen saturation of blood is an important physiological factor from which insights can be gained on ischemic processes common to cardiovascular disease. In addition, changes in oxygen saturation can also be indicative of pathological disease processes such as tumor growth, angiogenesis, and necrosis.

Blood oxygenation can also indicate a positive therapeutic response.

By spectrally differentiating the contribution of oxygenated and deoxygenated hemoglobin, MSOT offers the ability to analyze the blood oxygen saturation status of a mouse in real time in cross-sectional images while simultaneously allowing the visualization of anatomy and molecular probes.

Spectral decomposition of oxy-/deoxyhemoglobin

Images: Spectral decomposition of HbO2 and Hb shows regions of highly oxygenated Hb in the heart, allowing a functional characterization of cardiac activity in vivo.

Image left: Grayscale MSOT anatomical cross-section of mouse tail with pseudo-color overlay indicating multispectrally unmixed oxygenated (red) and deoxygenated (blue) hemoglobin. As expected, the artery contains nearly 100% oxygenated blood, while the oxygen saturation in the veins is considerably lower.

Image right: 
Spectral absorption of oxy- and deoxyhemoglobin. Shaded area depicts NIR wavelength range addressable by standard laser in MSOT systems.

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