Imaging pancreatic tumor targeting.

Due to its high incidence and devastating mortality rate, pancreatic cancer is an important research area for the scientific community. Orthotopic models are needed to accurately recapitulate the complexity of disease. Longitudinal study of orthotopic pancreatic ductal adenocarcinoma requires advanced non-invasive imaging approaches.

The amorphous shape of the pancreas as well as its limited contrast and perfusion however pose significant challenges to visualize it in vivo. Accurate quantification of biological processes at depth demands high resolution, sensitivity, and tomographic detection.

A recent series of studies conducted at the University of Louisville demonstrate the significant impact MSOT imaging brings to research in the area of pancreatic adenocarcinoma (see Publications & Abstracts on the right).

In the figure below MSOT visualizes the successful accumulation of fluorophore-conjugated EGF within a pancreatic tumor, and provides high-resolution images, which allow noninvasive, real-time comparison of signal within individual organs.

Visualizing tumor targeting of EGF probe

Hudson SV, Huang JS, Yin W, Albeituni S, Rush J, Khanal A, Yan J, Ceresa BP, Frieboes HB, McNally LR, Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography, Cancer Res. 2014 Nov 1;74(21):6271-9.

  • Anil Khanal et al.,
    Detection of pancreatic tumors in vivo with tumor targeted mesoporous silica-coated gold nanorods by multispectral optoacoustic tomography,
    Nano Res. 2015-8-26. DOI 10.1007/s12274-015-0886-8.
    Link
  • Charles W Kimbrough et al.,
    Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-low Insertion Peptide Probes in vivo,
    Clin Cancer Res. 2015 Jun 29. PII: clincanres.0314.2015.
    Link
  • Kimbrough CW et al.,
    Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1,
    J Surg Res. 2014 Oct 13. pii: S0022-4804(14)00623-4. DOI: 10.1016/j.jss.2014.06.045.
    Link
  • Shanice V Hudson et al.,
    Targeted Non-invasive Imaging of EGFR-expressing Orthotopic Pancreatic Cancer using Multispectral Optoacoustic Tomography (MSOT)
    ,
    Cancer Res. 2014 Sep 12. DOI: 10.1158/0008-5472.CAN-14-1656.
    Link

Abstracts

  • Detection of pancreatic cancer using acidic pH targeted probes detected using MSOT
    AACR 2015
    Link

  • Development of theranostic mesoporous silica nanoparticles for pancreatic cancer
    AACR 2015
    Link
  • Syndecan-1 targeted mesoporous silica-coated gold nanorods act as theranostic agents for in vivo detection of orthotopic pancreatic tumors using MSOT
    AACR 2015
    Link
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