Expand the scope of molecular imaging.

Due to its favorable characteristics in terms of spatiotemporal resolution, penetration depth, sensitivity and specificity, MSOT can be used for a multitude of applications.
 
The method impacts many areas in biological, pharmacological, medical and materials-related research. Key applications include:

Analyze parameters of disease progression across a wide range of biological mechanisms:

  • Tumor vascularity and perfusion
  • Hypoxia and apoptosis
  • Expression of extracellular markers
  • Immune cell recruitment

Monitoring blood flow and the beating heart in real time:

  • Vascular anatomy
  • Tissue perfusion and oxygenation
  • Plaque formation, content and vulnerability
  • Cardiac arrhythmia, ischemia

High-resolution imaging of deep brain structures, through intact skin and skull:

  • Glioblastoma
  • Perfusion, BBB permeability
  • Stroke
  • Neurodegenerative disease

Quantify kinetic processes in real time:

  • Probe uptake and elimination
  • Hepatic and renal function
  • Gastric motility
  • Multiplexing of probes

Observe changes of inflammation-related disease parameters:

  • Total blood volume
  • Hemoglobin concentration
  • Tissue oxygenation
  • Superficial and at depth

High-resolution optoacoustic skin imaging:

  • Endogenous optical contrast
  • Visualizing microvasculature
  • Hemoglobin content & oxygenation
  • Inflammation & cancer

Based on its strong roots in academic research and a close collaboration with partners in academia and pharma research, iThera Medical is continuously exploring new applications and is confident that MSOT will become the diagnostic imaging method of choice in a significant number of preclinical and clinical applications.

  • Knieling F et al.,
    Multispectral Optoacoustic Tomography for Assessment of Crohn’s Disease Activity,
    N Engl J Med. 2017 Mar 30;376(13):1294-6. DOI: 10.1056/NEJMc1612455.
    Link
  • Comenge J et al.,
    Preventing Plasmon Coupling Between Gold Nanorods Improves the Sensitivity of Photoacoustic Detection of Labelled Stem Cells In Vivo,
    ACS Nano. 2016 Jun 16. DOI: 10.1021/acsnano.6b03246.
    Link
  • Waldner MJ et al.,
    Multispectral optoacoustic tomography in Crohn's disease: Non-invasive imaging of disease activity,
    Gastroenterology. 2016 Jun 3. DOI: 10.1053/j.gastro.2016.05.047.
    Link
  • Neuschmelting V et al.,
    Lymph Node Micrometastases and In-Transit Metastases from Melanoma: In Vivo Detection with Multispectral Optoacoustic Imaging in a Mouse Model,
    Radiology. 2016 May 4:160191. DOI: 0.1148/radiol.2016160191.
    Link
  • Ingo Stoffels et al.,
    Metastatic status of sentinel lymph nodes in melanoma determined noninvasively with multispectral optoacoustic imaging,
    Sci. Transl. Med. 09 Dec 2015. DOI: 10.1126/scitranslmed.aad1278.
    Link
  • Scarfe L et al.,
    Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy,
    Sci. Rep. 5, 13601 (2015). DOI:10.1038/srep13601.
    Link
  • Press AT et al.,
    Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles,
    Nat Commun. 2014 Dec 3;5:5565. DOI: 10.1038/ncomms6565.
    Link
  • Shanice V Hudson et al.,
    Targeted Non-invasive Imaging of EGFR-expressing Orthotopic Pancreatic Cancer using Multispectral Optoacoustic Tomography (MSOT)
    ,
    Cancer Res. 2014 Sep 12. DOI: 10.1158/0008-5472.CAN-14-1656.
    Link
  • X. Luís Deán-Ben and Daniel Razansky,
    Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography,
    Light: Science & Applications (2014) 3, e137; doi:10.1038/lsa.2014.18.
    Link
  • Buehler A et al.,

    Real-time handheld multispectral optoacoustic imaging,


    Optics Letters 2013 May 1;38(9):1404-6. DOI: 10.1364/OL.38.001404.

    Link
  • Stritzker J et al.,

    Vaccinia Virus-mediated Melanin Production Allows MR and Optoacoustic Deep Tissue Imaging and Laser-induced Thermotherapy of Cancer,

    PNAS February 26, 2013 vol. 110 no. 9 3316-3320. DOI: 10.1073/pnas.1216916110.
    Link
  • Burton NC et al.,
    Multispectral Optoacoustic Tomography (MSOT) Brain Imaging and Characterization of Glioblastoma,

    Neuroimage, 2013 Jan 15;65:522-8. DOI: 10.1016/j.neuroimage.2012.09.053.
    Link
  • Herzog E et al.,

    Optical Imaging of Cancer Heterogeneity with MSOT,
    
Radiology. 2012 May;263(2):461-8. DOI: 10.1148/radiol.11111646.
    Link
  • Taruttis A et al.,

    Fast Multispectral Optoacoustic Tomography (MSOT) for Dynamic Imaging of Pharmacokinetics and Biodistribution in Multiple Organs,

    PLoS One 2012, 7(1):ee30491.
 DOI: 10.1371/journal.pone.0030491.
    Link
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