Participate in an imaging revolution.

iThera Medical offers the next generation in molecular imaging. 
Introducing MSOT - Multispectral Optoacoustic Tomography.

With its unique ability to accurately visualize and quantify tissue molecules, nanoparticles, biomarkers and optical agents, in vivo and in real time, through several centimeters of tissue, MSOT stands at the forefront of the next era in biomedical imaging.

Launch of Hybrid OA / US Technology

iThera Medical proudly announces the launch of its integrated optoacoustic / ultrasound (OPUS) imaging technology. The MSOT inVision 512-echo is the world's first hybrid tomographic OPUS imaging system, providing unparalelled and user-independent image quality, in real time, throughout the entire animal cross-section.

For more information: click here.

MSOT Small Animal Imaging

iThera Medical offers a range of small animal scanners with varying hardware and software configurations. All systems enable whole-body deep-tissue imaging in real time.

For more information: click here.

Opens video in new window

MSOT inVision Experiment Workflow

iThera Medical's MSOT imaging systems facilitate a wide variety of imaging applications as well as extensive data analysis, and are yet easy to use. To get a first-hand impression of the MSOT experiment procedure for small animal studies, follow this link: play video

Application Highlight: DCE-MSOT

MSOT has the capability to capture fast processes in vivo with high spatiotemporal resolution. Per-pixel analysis allows fitting of a pharmacokinetic model and calculation of parametric maps. Related applications include perfusion and probe targeting / clearance studies: see poster

MSOT Clinical Translation

Based on the real-time multispectral imaging technology proven in iThera Medical’s MSOT inSight / inVision small animal imaging systems, an MSOT imaging system for exploratory clinical use, the MSOT EIP (Experimental Imaging Platform), is now available.

For more information: click here.

xPLORE Probes

iThera Medical markets a proprietary line of probes optimized for the use with MSOT. The initial portfolio of three xPLORE© probes consists of two targeted reagents for the use in disease models related to cancer and inflammation as well as one blood pool agent with long circulation time.

For more information: click here.

  • Xie B et al.,
    Necrosis avid near infrared fluorescent cyanines for imaging cell death and their use to monitor therapeutic efficacy in mouse tumor models,
    Oncotarget. 2015 Oct 12. DOI: 10.18632/oncotarget.5498.
  • Merčep E. et al.,
    Whole-body live mouse imaging by hybrid reflection-mode ultrasound and optoacoustic tomography,
    Opt. Lett. 40, 4643-4646 (2015). DOI: 10.1364/OL.40.004643.
  • Merčep E. et al.,
    Hybrid Optoacoustic Tomography and Pulse–Echo Ultrasonography Using Concave Arrays,
    IEEE Trans Ultrason Ferroelectr Freq Control. 2015 Sep;62(9):1651-61. DOI: 10.1109/TUFFC.2015.007058.
  • Qiao An et al.,
    Multifunctional Magnetic Gd 3+ -Based Coordination Polymer Nanoparticles: Combination of Magnetic Resonance and Multispectral Optoacoustic Detections for Tumor-Targeted Imaging in vivo,
    Small. 2015 Sep 14. DPO: 10.1002/smll.201501491.
  • Anil Khanal et al.,
    Detection of pancreatic tumors in vivo with tumor targeted mesoporous silica-coated gold nanorods by multispectral optoacoustic tomography,
    Nano Res. 2015-8-26. DOI 10.1007/s12274-015-0886-8.
  • Scarfe L et al.,
    Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy,
    Sci. Rep. 5, 13601 (2015). DOI:10.1038/srep13601.
  • Charles W Kimbrough et al.,
    Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-low Insertion Peptide Probes in vivo,
    Clin Cancer Res. 2015 Jun 29. PII: clincanres.0314.2015.
  • Zhen Liu et al.,
    An efficient nano-based theranostic system for multi-modal imaging-guided photothermal sterilization in gastroinestinal tract,
    Biomaterials. 2015 Jul;56:206-18. DOI: 10.1016/j.biomaterials.2015.04.005.
  • Xosé Luís Deán-Ben et al.,
    High-frame rate four dimensional optoacoustic tomography enables visualization of cardiovascular dynamics and mouse heart perfusion,
    Sci Rep. 2015; 5:10133. DOI: 10.1038/srep10133.
  • Jiang Y et al.,
    Violacein as a genetically-controlled, enzymatically amplified and photobleaching-resistant chromophore for optoacoustic bacterial imaging,
    Sci Rep. 2015 Jun 19;5:11048. DOI: 10.1038/srep11048.
  • Lorenz Kirscher et al.,
    Doxycycline Inducible Melanogenic Vaccinia Virus as Theranostic Anti-Cancer Agent,
    Theranostics. 2015 Jun 15;5(10):1045-57. DOI: 10.7150/thno.12533.
    Page layout: 0
    Page level: 2