Participate in an imaging revolution.

iThera Medical offers the next generation in molecular imaging. 
Introducing MSOT - Multispectral Optoacoustic Tomography.

With its unique ability to accurately visualize and quantify tissue molecules, nanoparticles, biomarkers and optical agents, in vivo and in real time, through several centimeters of tissue, MSOT stands at the forefront of the next era in biomedical imaging.

RSOM Small Animal Imaging

iThera Medical's high-resolution RSOM Explorer imaging systems facilitate a wide variety of imaging applications as well as extensive data analysis, and are yet easy to use. For more information: click here or play video to get a first-hand impression of the RSOM experiment procedure for small animal studies.

MSOT Clinical Translation

Based on the real-time multispectral imaging technology proven in iThera Medical’s MSOT inSight / inVision small animal imaging systems, a handheld MSOT imaging system for translational and clinical research use, the MSOT Acuity, is now available (not yet approved as a medical device by FDA or CE).

For more information: click here or play video.

MSOT Small Animal Imaging

iThera Medical offers a range of small animal scanners with varying hardware and software configurations. All systems enable whole-body deep-tissue imaging in real time.

For more information: click here.

Hybrid OA / US Technology

iThera Medical recently launched an integrated OPtoacoustic / UltraSound (OPUS) imaging technology. The MSOT inVision 512-echo is the world's first hybrid tomographic OPUS imaging system, providing unparalelled and user-independent image quality, in real time, throughout the entire animal cross-section.

For more information: click here.

Application Highlight: DCE-MSOT

MSOT has the capability to capture fast processes in vivo with high spatiotemporal resolution. Per-pixel analysis allows fitting of a pharmacokinetic model and calculation of parametric maps. Related applications include perfusion and probe targeting / clearance studies: see poster

  • Ni R et al.,
    Cortical hypoperfusion and reduced cerebral metabolic rate of oxygen in the arcAβ mouse model of Alzheimer’s disease,
    Photoacoustics. 2018 Jun; 10: 38–47. DOI: 10.1016/j.pacs.2018.04.001.
    Link
  • Chan XHD et al.,
    Multimodal Imaging Approach to Monitor Browning of Adipose Tissue In Vivo,
    JLR, April 13, 2018. DOI: 10.1194/jlr.D083410.
    Link
  • Quiros I et al.,
    Optoacoustics delineates murine breast cancer models displaying angiogenesis and vascular mimicry,
    J Biophotonics. 2018 Mar 23:e201700359. DOI: 10.1002/jbio.201700359.
    Link
  • Reber J et al.,
    Non-invasive Measurement of Brown Fat Metabolism Based on Optoacoustic Imaging of Hemoglobin Gradients,
    Cell Metab. 2018 Mar 6;27(3):689-701.e4. DOI: 10.1016/j.cmet.2018.02.002.
    Link
  • Ni R et al.,
    Noninvasive detection of acute cerebral hypoxia and subsequent matrix-metalloproteinase activity in a mouse model of cerebral ischemia using multispectral-optoacoustic-tomography,
    Neurophotonics. 2018 Jan;5(1):015005. DOI: 10.1117/1.NPh.5.1.015005.
    Link
  • Aguirre J et al.,
    Assessing nailfold microvascular structure with ultra-wideband raster-scan optoacoustic mesoscopy,
    Photoacoustics, 2018 Jun; 10:31-37. DOI: 10.1016/j.pacs.2018.02.002.
    Link
  • Brannen A et al.,
    Correlation of 360-degree Surface Mapping In Vivo Bioluminescence with Multi-Spectral Optoacoustic Tomography in Human Xenograft Tumor Models,
    Sci Rep. 2018 Feb 20;8(1):3321. DOI: 10.1038/s41598-018-21668-4.
    Link
  • Duffy MJ et al.,
    Towards optimized naphthalocyanines as sonochromes for photoacoustic imaging in vivo,
    Photoacoustics, 2018 March; 9:49-61. DOI: 10.1016/j.pacs.2017.12.001.
    Link
  • Neuschmelting V et al.,
    WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice,
    Theranostics. 2018 Jan 1;8(3):723-734. DOI: 10.7150/thno.20386. eCollection 2018.
    Link
  • Knieling F et al.,
    Raster-Scanning Optoacoustic Mesoscopy for Gastrointestinal Imaging at High Resolution,
    Gastroenterology. 2018 Jan 5. DOI: 10.1053/j.gastro.2017.11.285.
    Link
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