Participate in an imaging revolution.

iThera Medical offers the next generation in molecular imaging. 
Introducing MSOT - Multispectral Optoacoustic Tomography.

With its unique ability to accurately visualize and quantify tissue molecules, nanoparticles, biomarkers and optical agents, in vivo and in real time, through several centimeters of tissue, MSOT stands at the forefront of the next era in biomedical imaging.

MSOT Small Animal Imaging

iThera Medical offers a range of small animal scanners with varying hardware and software configurations. All systems enable whole-body deep-tissue imaging in real time. For more details: click here.

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MSOT inVision Experiment Workflow

iThera Medical's MSOT imaging systems facilitate a wide variety of imaging applications as well as extensive data analysis, and are yet easy to use. To get a first-hand impression of the MSOT experiment procedure for small animal studies, follow this link: play video

MSOT Clinical Translation

Based on the real-time multispectral imaging technology proven in iThera Medical’s MSOT inSight / inVision small animal imaging systems, an MSOT imaging system for exploratory clinical use, the MSOT EIP (Experimental Imaging Platform), is now available. For more details: click here.

xPLORE Probes

iThera Medical markets a proprietary line of probes optimized for the use with MSOT. The initial portfolio of three xPLORE© probes consists of two targeted reagents for the use in disease models related to cancer and inflammation as well as one blood pool agent with long circulation time. For more details: click here.

Application Highlight: DCE-MSOT

MSOT has the capability to capture fast processes in vivo with high spatiotemporal resolution. Per-pixel analysis allows fitting of a pharmacokinetic model and calculation of parametric maps. Related applications include perfusion and probe targeting / clearance studies: see poster

  • Stefan Morscher, et al.,
    Semi-quantitative Multispectral Optoacoustic Tomography (MSOT) for volumetric PK imaging of gastric emptying,
    Photoacoustics, September 2014. DOI: 10.1016/j.pacs.2014.06.001.
  • Chris Jun Hui Ho et al.,
    Multifunctional Photosensitizer-Based Contrast Agents for Photoacoustic Imaging,
    Scientific Reports 2014. DOI:10.1038/srep05342.
  • Maji, S. K. et al.,
    Upconversion Nanoparticles as a Contrast Agent for Photoacoustic Imaging in Live Mice,
    Adv. Mater. 2014. DOI: 10.1002/adma.201400831.
  • Moritz Kneipp et al.,
    Functional Real-Time Optoacoustic Imaging of Middle Cerebral Artery Occlusion in Mice,
    PLoS One 2014 Apr 28. DOI: 10.1371/journal.pone.0096118.
  • Alexander Dima et al.,
    Multispectral optoacoustic tomography at 64, 128, and 256 channels,
    J Biomed Opt. 2014 Mar;19(3):36021. DOI: 10.1117/1.JBO.19.3.036021.
  • Nam-Young Kang et al.,
    A macrophage uptaking near-infrared chemical probe CDnir7 for in vivo imaging of inflammation,
    Chem. Commun., 2014; DOI: 10.1039/C4CC02038C.
  • X. Luís Deán-Ben and Daniel Razansky,
    Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography,
    Light: Science & Applications (2014) 3, e137; DOI:10.1038/lsa.2014.18.
  • Deliolanis NC et al.,
    Deep-Tissue Reporter-Gene Imaging with Fluorescence and Optoacoustic Tomography: A Performance Overview,
    Mol Imaging Biol. 2014 Mar 8. DOI: 10.1007/s11307-014-0728-1.
  • Wu W, Driessen W, Jiang X,
    Oligo(ethylene glycol)-Based Thermo-Sensitive Dendrimers and Their Tumor Accumulation and Penetration,
    J Am Chem Soc. 2014 Feb 7; DOI: 10.1021/ja411457r.
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