Participate in an imaging revolution.

iThera Medical offers the next generation in molecular imaging. 
Introducing MSOT - Multispectral Optoacoustic Tomography.

With its unique ability to accurately visualize and quantify tissue molecules, nanoparticles, biomarkers and optical agents, in vivo and in real time, through several centimeters of tissue, MSOT stands at the forefront of the next era in biomedical imaging.

MSOT Small Animal Imaging

iThera Medical offers a range of small animal scanners with varying hardware and software configurations. All systems enable whole-body deep-tissue imaging in real time.

For more information: click here.

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MSOT inVision Experiment Workflow

iThera Medical's MSOT imaging systems facilitate a wide variety of imaging applications as well as extensive data analysis, and are yet easy to use. To get a first-hand impression of the MSOT experiment procedure for small animal studies, follow this link: play video

MSOT Clinical Translation

Based on the real-time multispectral imaging technology proven in iThera Medical’s MSOT inSight / inVision small animal imaging systems, an MSOT imaging system for exploratory clinical use, the MSOT EIP (Experimental Imaging Platform), is now available.

For more information: click here.

xPLORE Probes

iThera Medical markets a proprietary line of probes optimized for the use with MSOT. The initial portfolio of three xPLORE© probes consists of two targeted reagents for the use in disease models related to cancer and inflammation as well as one blood pool agent with long circulation time.

For more information: click here.

Application Highlight: DCE-MSOT

MSOT has the capability to capture fast processes in vivo with high spatiotemporal resolution. Per-pixel analysis allows fitting of a pharmacokinetic model and calculation of parametric maps. Related applications include perfusion and probe targeting / clearance studies: see poster

  • Press AT et al.,
    Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles,
    Nat Commun. 2014 Dec 3;5:5565. DOI: 10.1038/ncomms6565.
  • Yiye Li et al.,
    Localized Electric Field of Plasmonic Nanoplatform Enhanced Photodynamic Tumor Therapy,
    ACS Nano. 2014 Nov 13. DOI: 10.1021/nn5047647.
  • Beziere N et al.,
    Dynamic imaging of PEGylated indocyanine green (ICG) liposomes within the tumor microenvironment using multi-spectral optoacoustic tomography (MSOT),
    Biomaterials. 2014 Oct 23;37C:415-424. DOI: 10.1016/j.biomaterials.2014.10.014.
  • Shanice V Hudson et al.,
    Targeted Non-invasive Imaging of EGFR-expressing Orthotopic Pancreatic Cancer using Multispectral Optoacoustic Tomography (MSOT)
    Cancer Res. 2014 Sep 12. DOI: 10.1158/0008-5472.CAN-14-1656.
  • Stefan Morscher et al.,
    Semi-quantitative Multispectral Optoacoustic Tomography (MSOT) for volumetric PK imaging of gastric emptying,
    Photoacoustics, September 2014. DOI: 10.1016/j.pacs.2014.06.001.
  • N. Beziere et al.,
    Optoacoustic Imaging and Staging of Inflammation in a Murine Model of Arthritis,
    Arthritis Rheumatol. 2014 Aug;66(8):2071-8. DOI: 10.1002/art.38642.
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