Participate in an imaging revolution.

iThera Medical offers the next generation in molecular imaging. 
Introducing MSOT - Multispectral Optoacoustic Tomography.

With its unique ability to accurately visualize and quantify tissue molecules, nanoparticles, biomarkers and optical agents, in vivo and in real time, through several centimeters of tissue, MSOT stands at the forefront of the next era in biomedical imaging.

RSOM Small Animal Imaging

iThera Medical's high-resolution RSOM Explorer imaging systems facilitate a wide variety of imaging applications as well as extensive data analysis, and are yet easy to use. For more information: click here or play video to get a first-hand impression of the RSOM experiment procedure for small animal studies.

MSOT Clinical Translation

Based on the real-time multispectral imaging technology proven in iThera Medical’s MSOT inSight / inVision small animal imaging systems, a handheld MSOT imaging system for translational and clinical research use, the MSOT Acuity, is now available (not yet approved as a medical device by FDA or CE).

For more information: click here or play video.

MSOT Small Animal Imaging

iThera Medical offers a range of small animal scanners with varying hardware and software configurations. All systems enable whole-body deep-tissue imaging in real time.

For more information: click here.

Hybrid OA / US Technology

iThera Medical recently launched an integrated OPtoacoustic / UltraSound (OPUS) imaging technology. The MSOT inVision 512-echo is the world's first hybrid tomographic OPUS imaging system, providing unparalelled and user-independent image quality, in real time, throughout the entire animal cross-section.

For more information: click here.

Application Highlight: DCE-MSOT

MSOT has the capability to capture fast processes in vivo with high spatiotemporal resolution. Per-pixel analysis allows fitting of a pharmacokinetic model and calculation of parametric maps. Related applications include perfusion and probe targeting / clearance studies: see poster

  • Neuschmelting V et al.,
    WST11 Vascular Targeted Photodynamic Therapy Effect Monitoring by Multispectral Optoacoustic Tomography (MSOT) in Mice,
    Theranostics. 2018 Jan 1;8(3):723-734. DOI: 10.7150/thno.20386. eCollection 2018.
    Link
  • Dey S et al.,
    The vascular disrupting agent combretastatin A-4 phosphate causes prolonged elevation of proteins involved in heme flux and function in resistant tumor cells,
    Oncotarget. 2018; 9:4090-4101. DOI: 10.18632/oncotarget.23734
    Link
  • Yang Q et al.,
    Porous Au@Pt Nanoparticles: Therapeutic Platform for Tumor Chemo-Photothermal Co-Therapy and Alleviating Doxorubicin-Induced Oxidative Damage,
    ACS Appl Mater Interfaces. 2018 Jan 10;10(1):150-164. DOI: 10.1021/acsami.7b14705.
    Link
  • Knieling F et al.,
    Raster-Scanning Optoacoustic Mesoscopy for Gastrointestinal Imaging at High Resolution,
    Gastroenterology. 2018 Jan 5. DOI: 10.1053/j.gastro.2017.11.285.
    Link
  • Dong L et al.,
    Multifunctional Cu-Ag2S nanoparticles with high photothermal conversion efficiency for photoacoustic imaging-guided photothermal therapy in vivo,
    Nanoscale. 2018 Jan 3;10(2):825-831. DOI: 10.1039/c7nr07263e.
    Link
  • Tan L et al.,
    Renal-clearable quaternary chalcogenide nanocrystal for photoacoustic/magnetic resonance imaging guided tumor photothermal therapy,
    Biomaterials. 2018 Jan 2;159:108-118. DOI: 10.1016/j.biomaterials.2018.01.003.
    Link
  • Napp J et al.,
    Fluorescence- and multispectral optoacoustic imaging for an optimised detection of deeply located tumours in an orthotopic mouse model of pancreatic carcinoma,
    Int J Cancer. 2017 Dec 26. DOI: 10.1002/ijc.31236.
    Link
  • Ovsepian SV et al.,
    Pushing the Boundaries of Neuroimaging with Optoacoustics,
    Neuron. 2017 Dec 6;96(5):966-988. DOI: 10.1016/j.neuron.2017.10.022.
    Link
  • Chen L et al.,
    Biodegradable Nanoagents with Short Biological Half-Life for SPECT/PAI/MRI Multimodality Imaging and PTT Therapy of Tumors,
    Small. 2017 Dec 1. DOI: 10.1002/smll.201702700.
    Link
  • Chen Z et al.,
    Hybrid system for in vivo epifluorescence and 4D optoacoustic imaging,
    Opt Lett. 2017 Nov 15;42(22):4577-4580. DOI: 10.1364/OL.42.004577.
    Link
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