Participate in an imaging revolution.

iThera Medical offers the next generation in molecular imaging. 
Introducing MSOT - Multispectral Optoacoustic Tomography.

With its unique ability to accurately visualize and quantify tissue molecules, nanoparticles, biomarkers and optical agents, in vivo and in real time, through several centimeters of tissue, MSOT stands at the forefront of the next era in biomedical imaging.

MSOT Clinical Translation

Based on the real-time multispectral imaging technology proven in iThera Medical’s MSOT inSight / inVision small animal imaging systems, an MSOT imaging system for clinical use, the MSOT Acuity, is now available.

For more information: click here or play video.

MSOT Small Animal Imaging

iThera Medical offers a range of small animal scanners with varying hardware and software configurations. All systems enable whole-body deep-tissue imaging in real time.

For more information: click here.

Opens video in new window

MSOT inVision Experiment Workflow

iThera Medical's MSOT imaging systems facilitate a wide variety of imaging applications as well as extensive data analysis, and are yet easy to use. To get a first-hand impression of the MSOT experiment procedure for small animal studies, follow this link: play video

Hybrid OA / US Technology

iThera Medical recently launched an integrated OPtoacoustic / UltraSound (OPUS) imaging technology. The MSOT inVision 512-echo is the world's first hybrid tomographic OPUS imaging system, providing unparalelled and user-independent image quality, in real time, throughout the entire animal cross-section.

For more information: click here.

Application Highlight: DCE-MSOT

MSOT has the capability to capture fast processes in vivo with high spatiotemporal resolution. Per-pixel analysis allows fitting of a pharmacokinetic model and calculation of parametric maps. Related applications include perfusion and probe targeting / clearance studies: see poster

xPLORE Probes

iThera Medical markets a proprietary line of probes optimized for the use with MSOT. The initial portfolio of three xPLORE© probes consists of two targeted reagents for the use in disease models related to cancer and inflammation as well as one blood pool agent with long circulation time.

For more information: click here.

  • Bhutiani N et al.,
    Non-invasive Imaging of Colitis using Multispectral Optoacoustic Tomography,
    J Nucl Med. 2016 Dec 1. PII: jnumed.116.184705.
  • Yang W et al.,
    Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy,
    ACS Nano. 2016 Oct 28. DOI: 10.1021/acsnano.6b05760.
  • Chuang Gao et al.,
    Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging,
    Cancer Biol Med. 2016 Sep; 13(3): 349–359. DOI: 10.20892/j.issn.2095-3941.2016.0048.
  • Chuah SY et al.,
    Structural and functional 3D mapping of skin tumours with non-invasive multispectral optoacoustic tomography,
    Skin Res Technol. 2016 Nov 2. DOI: 10.1111/srt.12326.
  • Chen J et al.,
    Gold Nanorods-Based Gene Carriers with the Capability of Photoacoustic Imaging and Photothermal Therapy,
    ACS Appl Mater Interfaces. 2016 Oct 24. DOI: 10.1021/acsami.6b10166.
  • Gao S et al.,
    A non-viral suicide gene delivery system traversing the blood brain barrier for non-invasive glioma targeting treatment,
    J Control Release. 2016 Oct 26. DOI: 10.1016/j.jconrel.2016.10.027.
  • Li Y et al.,
    Targeted polydopamine nanoparticles enable photoacoustic imaging guided chemo-photothermal synergistic therapy of tumor,
    Acta Biomater. 2016 Oct 6. DOI: 10.1016/j.actbio.2016.10.010.
  • Yong Ni et al.,
    Naphthalene-fused BODIPY near-infrared dye as a stable contrast agent for in vivo photoacoustic imaging,
    Chem. Commun., 2016,52, 11504-11507. DOI: 10.1039/C6CC05126J.
  • Li Z et al.,
    Multimodal Imaging-Guided Antitumor Photothermal Therapy and Drug Delivery Using Bismuth Selenide Spherical-Sponge,
    ACS Nano. 2016 Sep 30. DOI: 10.1021/acsnano.6b05427.
  • Du Y et al.,
    DNA-Nanostructure–Gold-Nanorod Hybrids for Enhanced In Vivo Optoacoustic Imaging and Photothermal Therapy
    Adv Mater. 2016 Sep 28. DOI: 10.1002/adma.201601710.
    Page layout: 0
    Page level: 2